Porreca E, Di Febbo C, Mincione G, Reale M, Guglielmi MD,
Castellani ML, Cuccurullo F, Colletta G
Increased expression of TGF-beta isoforms by human monocytes of
hypertensive patients
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
Transforming
growth factor b is a regulator of extracellular matrix component
synthesis. Interstitial fibrosis is a common feature of pressure
overload hypertrophy and TGF-b, may be involved in the development of
cardiovascular remodeling associated to hypertension. Since
inflammatory cells, such as peripheral blood monocytes, are potential
sources of TGF-b in vivo, we studied TGF b mRNA gene expression in the
ex-vivo cell culture of human nonactivated monocytes of hypertensive
patients.
Eight hypertensive patients with concentric LV hypertrophy
and eight matched control healthy subjects were analyzed.
The expression of TGF-b isoforms was evaluated by Northern blot
hybridization of total mRNA extracted from cultures of unstimulated
peripheral monocytes after 24 hrs of incubation time. b1, b2 and b3
isoforms were expressed in the peripheral blood monocytes.
TGF-b1 and TGF-b2 mRNA expression were significantly induced in the
monocytes
fractions of hypertensive patients respect to controls (1.7 ñ 0.5 fold
and 2.2 ñ 0.3 respectively, P < 0.01); TGF-b3 mRNA expression was
unchanged in hypertensive patients respect to controls.
Comment:
These data are consistent with the hypothesis that the induction of TGFb
isoforms,
particularly b1 and b2, in hypertensive patients may be associated with
ventricular remodeling hypertrophy (Carmine Zoccali, M.D, Reggio
Calabria, Italy).
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16th Scientific Meeting of the International Society of Hypertension
H: Pathophysiology :
Heart in hypertension