Soro A, Glorioso N, Ingram MC, Fraser R
Different plasma corticosteroid patterns in normotensive and
hypertensive subjects
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
Possible partial defects in corticosteroid biosynthesis in essential
hypertension have been reported but the impact of these defects in the
hypertensive population is unknown. The authors studied 117 essential
hypertensive patients and 49 normotensive subjects with negative
family history of hypertension.
The ratio Deoxycortisol/Cortisol was higher in hypertensives (which
suggests 11 beta hydroxylase deficiency) than in healthy controls (3.4 vs
1.3, P<0.001) but, in contrast, the ratio of
deoxycorticosterone/corticosterone was not. In hypertensives, PRA was lower
than
in normotensives but plasma ALDO levels were similar. Plasma corticosterone
concentration was higher (although still within a random normal range)
and cortisol lower in HT than in NT. The abnormality of steroid
pattern in HT did not conform to classic 11 beta hydroxylase deficiency.
Comment: Slightly but significantly increased corticosterone
levels may be
relevant to the development of
hypertension and suggest further studies of the genetics of adrenal
hydroxylase (Carmine Zoccali,
M.D, Reggio Calabria, Italy).
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16th Scientific Meeting of the International Society of Hypertension
H: Special problems :
Endocrine hypertension