Stamler J, Elliott P, Kesteloot H, Nichols R, Glaeys G, Dyer
AR, Stamler R, for the INTERSALT Group
Inverse relationship between dietary protein markers and blood
pressure -- findings for 10,020 men and women in Intersalt
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
This analysis of the INTERSALT data base investigates the relation
between blood pressure (BP) with markers of dietary protein. Three
measurements of dietary protein in 24-hour urines were considered:
total nitrogen (N) and urea as indices of total protein intake, and
sulphate as index of S-containing dietary amino acids. Repeat
examination in a random 8% of participants was done to assess
reliability and correct for regression-dilution bias.
Significant
independent inverse relationships were found between BP (systolic,
diastolic) and both 24-hour urinary total nitrogen and urea N, with
adjustment for age, sex, alcohol intake, body mass, 24-hour urinary
Na, K, Ca, Mg. With multivariate adjustment also for
regression-dilution bias, it was estimated that systolic BP/diastolic
BP was on average 3.0/2.5 mmHg lower for persons with dietary total
protein intake 30% above the overall mean compared to those 30% below
the overall mean (12.94 vs. 6.96 g/day urinary total N, equivalent to
81 vs. 44 g/day dietary protein). Relations of these markers to BP
were not significantly different for individuals with lower and higher
body mass index, and for persons from
samples with lower and higher BMI. For the association of these
markers with diastolic BP, results were similar for younger (ages 20-)
and older (age 40-) persons, and for women and men. For their relation
to systolic pressure, regression coefficients were larger for those
ages 40-than for those ages 20-, and for women than men.
Non-significant inverse relationships were recorded for urinary
sulphate and BP.
Comment:
These INTERSALT findings lend support to the
hypothesis that higher dietary protein intake has favourable _not
adverse _influences on blood pressure (Carmine Zoccali, M.D,
Reggio Calabria, Italy).
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16th Scientific Meeting of the International Society of Hypertension
H: Non drug therapy :
Dietary/electrolyte therapy