Wong KK, Summers KM, Burstow DJ, West MJ
An angiotensin-II type 1 microsatellite allele is associated
with lower blood pressure
16th Scientific Meeting of the International Society of Hypertension
ISH Abstract Book
(Jun) 16: 1996
This study examines the relationship between angiotensin-II type1 receptor
(A2R) microsatellite polymorphism and blood pressure or left
ventricular hypertrophy. Subjects (n = 146, mean age = 59 ñ 12 yrs,
M/F = 1.4/1) with a range of blood pressures (BP) were recruited. The A2 R
microsatellite alleles (A, 132 bp to H, 146 bp) were determined from
genomic DNA using established methods. The association between blood
pressure or wall thickness (RWT) was examined for each allele according to
the presence
or absence of the allele.
No relationship was observed between
A,C,D,E,F,G, or H genotypes and BP or RWT. Subjects with BB or Bb
genotype (n = 27) had lower systolic and diastolic BP than bb subjects
(n = 119). b represents all alleles other than B. The independent
variables identified which
predicted systolic BP were A2R Bb genotype, age, body mass index, and gender.
However, the number of hypotensive agents taken was not an
independent variable in this study population. Although
RWT was also lower in BB or Bb compared with bb genotype,
multiple regression analysis attributed this
relationship to subjects's age and systolic BP.
Comment: In addition to the known influences of age and body
mass index
on BP, A2R BB or Bb genotype is also an independent genetic marker for
lower blood pressure suggesting that the A2R gene may influence BP
control (Carmine Zoccali, M.D, Reggio Calabria, Italy).
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16th Scientific Meeting of the International Society of Hypertension
H: Pathophysiology :
Genetics