Ahmad S, Keech PR, Hynes J, Blagg CR
Serum albumin and peritoneal equilibration test
XVIth Annual CAPD Conference
Perit Dial Int Suppl 2
(Feb) 16:S89 1996
The authors of this study collected data on dialysate to plasma
creatinine ratio (D/P) and serum albumin in 40 new patients within six months
of starting CAPD.
They demonstrated that patients with
high-high average PET values had significantly lower serum albumin levels
than those with low-low
average values (2.8 vs 3.3 g/dl). The authors propose that the low serum
albumin levels in the high
transporters could not due to albumin loss from the peritoneum because
patients were new to CAPD.
They hypothesize that albumin may be a factor influencing transport
characteristics of the
peritoneal membrane.
Comment: Solute transport is dependent on solute charge and protein
binding. Creatinine is
neither charged nor protein bound so it is not intuitively clear how albumin
might control
creatinine mass transfer. Further studies of this topic need to be
performed.
(James L. Winchester, M.D.)
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XVIth Annual CAPD Conference
Basic peritoneal dialysis :
PET testing
CRF by organ system :
Nutrition