Chau KF, WOng KM, Choi KS, Li CS
Treatment of exit-site infection: a randomized trial on
ampicillin plus cloxacillin, ofloxacin, and local mupirocin
XVIth Annual CAPD Conference
Perit Dial Int Suppl 2
(Feb) 16:S66 1996
This was a small randomized study of treatment of exit site infections. Exit
site infection was not
defined. Patients were reandomized into 3 treatment groups: (1) oral
cloxacillin and ampicillin
(presumably for 1 week); (2) oral ofloxacine for 9 days;
or (3)local mupirocin for 1 week.
Results:
Ofloxacin: cured: 82%
Ampicillin/cloxacillin: cured: 58%
Local mupirocin: cured: 67%
The definition of cure was not provided in the abstract, and recurrence rate
and duration of
follow-up were not mentioned.
No mention was made as to whether or not the peritonitis rates changed during
any of the treatment
periods.
Comment: The use of oral antibiotics (especially combinations or wide
spectrum antibiotics)
has a built-in danger of increasing patient susceptibility to fungal
infections. It was not clear in
this study (in the absence of peritonitis data) what the cost-benefit
ratio of any of these therapies was.
(Stephen I. Vas, M.D.)
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XVIth Annual CAPD Conference
Basic peritoneal dialysis :
Peritonitis and exit-site infection