deBoer AW, van Schajik TCJG, Willems JL, Reddinguis RE,
Monnens LAH, Schroeder CH
Standardization of pediatric PET test: Results with a dwell
volume of 1200 mL/m2
XVIth Annual CAPD Conference
Perit Dial Int Suppl 2
(Feb) 16:S6 1996
In adult CAPD patients standard dwell volumes of 2000 ml are used. In
children volumes are usually prescribed in relation to body weight using
40 ml/kg as a guideline. The authors set up a protocol to evaluate
if fluid kinetics in
children was different from adults when using body surface area instead of
body weight to prescribe dwell volumes.
One group of children (n=11) was prescribed a dwell volume according to
body surface area (1213 +/_ 49 ml/m2).
The other group (n=13) was prescribed a volume based on weight (40.3 +/- 0.3
ml/kg).
No difference as observed between the two groups for transcapillary
ultrafiltration (TCUF) and clearances. When dwell volume was based on BSA,
there was no correlation between TCUF and age, whereas TCUF was positively
correlated with age
when dwell volume was prescribed based on weight.
The authors conclude that fluid kinetics in children are not different from
adults and that the apparent relationship between age and TCUF is due to
prescription of dwell
volume based on weight instead of BSA.
Comment: This work is original and interesting as it gives us a method
for
standardizing peritoneal equilibration tests in children, whatever their
age.
From a statistical point of view the study leaves something to be desired,
as it is based on comparison of means of two different groups each with a
smalln
number of cases. It would have been more meaningful to perform paired tests
with
dwell volumes based on both BSA and weight in the same children.
(Christian Verger, M.D.,
Pointoise, France)
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XVIth Annual CAPD Conference
Basic peritoneal dialysis :
PET testing
CRF by problem area :
CRF in infants and children