Khan A, Rault RM, Bernardini J, Piraino B
Seroconversion rates with hepatitis B vaccination in PD
patients
XVIth Annual CAPD Conference
Perit Dial Int Suppl 2
(Feb) 16:S72 1996
The Pittsburgh group studied the response rate to recombinant hepatitis B
vaccine in in 47 PD and 50
Hd patients. The conversion rate was significantly lower in PD patients
(53%) vs. HD patients
(74%). The results were surprising in that, in 1987, the same group found
equal conversion rates
(approximately 73%) in their HD and PD patients (a different non-recombinant
HB vaccine was used).
Comment: It is difficult to assess if the better response rate of HD
patients in the present
study was due to a peculiarity of the vaccine, or to perhaps better Kt/V now
for HD patients than in
1987 (adequacy data are not given). However, the results suggest that HB
vaccination of PD patients
is only moderately successful on initial attempt, even when 40 ug IM are
given x 4.
(John T. Daugirdas, M.D., University of Illinois at Chicago)
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XVIth Annual CAPD Conference
CRF by organ system :
GI/Liver, Hepatitis