The prevalences and clinical characteristics of ANCAs in lupus nephritis
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:83A 1997
Chin et al from Seoul National University Hospital evaluated lupus nephritis patients for ANCA, anti-MPO and anti-lactoferrin antibody in 59 patients (8 without nephritis). ANCA was positive in 37.3% of patients with nephritis, most of whom had pANCA. With these patients having higher anti-dsDNA antibody titers. This was associated with DPLN. p-ANCA positivity was a marker for deterioration of renal function. Patients with anti-lactoferrin antibody had lower serum creatinines.
Comment: This study suggests that SLE patients with positive ANCA are more likely to have nephritis and anti-dsDNA antibodies. p-ANCA was associated with worse prognosis and DPLN. Anti-lactoferrin antibody was associated with better renal function. This may help discern what use ANCA plays in the evaluation of lupus nephritis. (N. Kevin Krane, M.D., Tulane University School of Medicine)
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ASN 30th Annual Meeting, San Antonio
Proteinuria/Hematuria : Lupus nephritis
Proteinuria/Hematuria : Vasculitis (Wegener's PAN, etc.)