ASN 30th Annual Meeting, San Antonio --November, 1997

Selected Abstracts


Preadolescent and adolescent

h Detection and prevalence of arterial hypertension in school age children from Braganca Paulista, Sao Paolo, Brazil

Kidney in hypertension

h Differences in glomerular membrane permeability responses to a non- dihydropyridine (NDHP) and dihydropyridie (DHP) calcium channel antagonist (CCA) in patients with diabetic nephropathy:
h Outcome of scleroderma renal crisis (SRC).
h Angiotensin II acts against both the afferent and efferent arterioles via type IA receptor to the same extent, not with predominance of the efferent arteriole--direct evidence using AT1a
h Is microalbuminuria a predictor of cardiovascular and renal events in essential hypertension (EH)?
h Microalbuminuria (MA) is a marker for cardiovascular (CV) risk in young adults.

Sympathetic nervous system

h Evidence against elevated sympathetic activity in borderline hypertension.

Renovascular hypertension

h High grade renal artery atherosclerosis in patients with chronic renal insufficiency is not characterized by a rapid (< 6 months) decline in renal function
h Beneficial effect of ace inhibition on survival of patients with renovascular hypertension (RVH).
h Intravascular stents in the treatment of renal artery stenosis (RAS).
h Detection of severe bilateral atherosclerotic renovascular disease by ACE-inhibitor induced renal dysfunction.

ACE inhibitors

h ACE I/D polymorphism and short-term renal response to ACE inhibition; Role of sodium status
h Safety of losartan in hypertensive patients with asymptomatic hyperuricemia.


h Age-race subgroup vs renin profile as predictors of blood pressure response to antihypertensive therapy in 292 patients: Results of the VA cooperative study.
h Renin profile as a predictor of blood pressure response to antihypertensive therapy in 1292 patients: Results of the VA cooperative study.

Dialysis, Chronic Renal Failure

Vascular Access: graft/fistula

d Silent infection in clotted hemodialysis access graft.
d Management of cuffed tunned dialysis catheter infection.
d A comparison between PTFE and denatured homologous vein (DVH) grafts for hemodialysis access: A randomised multicenter trial.
d Hemodialysis vascular access and surgical training.
d The value of low intra-access pressure (IAP) in detecting and excluding low access blood flow.
d Clinical study of a hematocrit (H)-based method to determine vascular access blood flow rates (QA) without saline injection (SI).
d Brachytherapy in the prevention of re-stenosis after percutaneous transluminal angioplasty (PTA) for central venous stenosis (CVS).

(Intermittent) dialysis for ARF

d Indication for dialysis influences outcome from acute renal failure (ARF) the ICU; Results from a radomized multicenter trial.
d Acute peritoneal access and high frequency peritoneal dialysis in intensive care patients
d Urea disequilibrium contributes to underdialysis in the intensive care unit.
d Dose of intermittent hemodialysis (IHD) and outcome of acute renal failure (ART): A prospective randomized study.

Vascular Access: venous

d Factors influencing function and survival of temporary hemodialysis catheters.

Complications (acute)

d pH of the washing solutions for dialysis filters and generation of vasodilatory mediators (bradykinin and nitric oxide): Role in first use syndrome
d Midodrine as a treatment for intradialytic hypotension.
d Plasma sodium (CpNa) "setpoint": Relationship to interdialytic weight gain (IWG) and mean arterial pressure (MAP) in hemodialysis patients (HDP).
d Neurologic symptoms and death associated with the use of cellulose acetate dialyzers.

Adequacy, prescription, urea kinetics

d Mortal risk and URR: Differences among demographic groups.
d Sraightening out the J-shaped curve: The relation between dialysis dose and mortality is dependent on total body water.
d Effect of changes in dialytic frequency, duration and flow rates on solute kinetics and effective clearances.
d Effect of vascular access type and blood draw method on recirculation and rebound in the HEMO study.
d Dialysate side Kt/V -- a whole body approach

Reuse, theory and practice

d Increases in membrane porosity after reuse with citric acid and heat.


d Falsely elevated troponin T but not troponin I in patients with renal impairment
d Renalism: Bias in the utilization of inpatient cardiac catheterization (CATH) in patients with chronic renal insufficiency (CRI).
d Diagnosis of cardiac injury in renal disease patients: Value of cardiac troponins.
d Cardiac troponin I (CTI) is a reliable marker of acute myocardial infarction (MI) in end stage renal disease (ESRD) patients.
d Higher levels of antioxidant defenses in chronic renal patients in hemodialysis treated with ACEi.
d Acute effects of high dose furosemide on residual renal function in CAPD patients.


d Frequent IV iron dosing is associated with higher infectious deaths.
d Hematocrit level is a predictive factor for future hospitalization events.
d Patient survival is associated with hematocrit (HCT) level.
d Sodium ferric gluconate complex in sucrose: Safer than iron dextran.
d Subcutaneous (SC) versus intravenous (IV) administration of recombinant human erythropoietin (rHuEPO) in hemodialysis (HD) patients (pts).
d Intravenous iron hydroxysaccharate: Establishing the optimum dose.
d Efficacy of frequent dosing of iron dextran on epogen dose and cost on a stable vs mixed maintenance hemodialysis (HD) population.
d Parenteral iron causes increased lipid peroxidation in hemodialysis patients.

Bone disease/aluminum

d An open label, cross-over study of the new phosphate binder RenaGel in the management of hyperphosphatemia in ESRD patients.
d Suppression of parathormone by calcitriol therapy in hemodialysis patients: A meta-analysis.
d Downregulation of osteoblast PTH/PTHrP receptor mRMA expression in renal failure.
d Experimental evidence for strontium (Sr) to play a role in the development of dialysis related osteomalacia (OM).
d Pharmacokinetics and pharmacodynamics of pamidronate disodium in hemodialysis.
d Use of one-alpha-hydroxyvitamin D2 (1alpha D2) in 121 hemodialysis patients with secondary hyperparathyroidism: A phase 3 trial.
d 19-Nor safely and effectively reduces PTH levels in hemodialysis patients.

Drug use in CRF

d Possible neurologic effects of fentanyl in dialysis patients

Infections (other than hepatitis, peritonitis)

d Cefazolin for empiric treatment of HD-related infections: Efficacy and blood concentrations.
d Pharmacokinetics of quinupristin/dalfopristin (Syndercid RP 59500) in patients receiving continuous ambulatory peritoneal dialysis (CAPD).

CRF in infants and children

d Acquired cystic kidney disease (ACKD) in children undergoing dialysis and with renal transplants
d Intradialytic (ID) weight and ambulatory blood pressure (BPM) correlate positively in children and adolescents receiving hemodialysis.


d Zinc supplementation reduces plasma cortisol levels in zinc- deficient patients with end-stage renal disease (ESRD)
d Subjective global assessment (SGA) does not correlate with routine biochemical markers in evaluating nutrition in hemodialysis (HD) patients (PTS).
d Effect of L-carnitine on protein catabolic rate (PCR) in chronic hemodialysis patients (CHD).
d Effect of oral supplementation on nutritional indices in chronic hemodialysis patients.
d Transferrin (TF) and serum prealbumin (PAlb) are early predictors of albumin (Alb) in chronic hemodialysis patients (CHD).
d High body mass index (BMI) does not adversely affect cardiovascular (CV) and all-cause mortality in hemodialysis patients
d Plasma carnitine as a marker of protein malnutrition.
d Significant correlation between near-infrared interactance and nutritional parameters in hemodialysis patients.

Outcomes (Morbidity, Mortality)

d A multinational hemodialysis patient survival comparison.
d Income is a very important independent variable that affects survival of patients with ESRD.

Surgery in ESRD

d Surgical mortality and morbidity in patients with end-stage renal disease

PD solutions, equipment

d Overestimation of blood glucose measurements by auto-analyser method in CAPD patients (pts) treated with icodextrin.

Peritonitis and exit-site infection

d Effect of lactate or bicarbonate buffered CAPD solutions on netilmycin bactericidal activity/

Chronic PD regimens, adequacy, modeling

d The importance of residual renal function for survival in patients on peritoneal dialysis.
d Admitted noncompliance [NC] with CAPD exchanges is more common in US than Canadian patients.
d A description of the delivery of peritoneal dialysis (PD) in the US.


d End stage renal failure: Discrepancy between theoretical practice and reality
d The angiotensin-converting-enzyme (ACE) inhibitor ramipril slows the rate of GFR decline and the progression to end stage renal failure (ESRF) in proteinuric, non-diabetic chronic renal

Kidney in hypertension

d Effect of various antihypertensive drugs on microalbuminuria and progression of renal disease in essential hypertension (EH)

Clinical Nephrology

Cyclosporine, ARF in transplant patients

c Cyclosporine (CsA)-induced nephrotoxicity (NT) in auto-immune diseases (AID): A meta-analysis.
c Bioequivalence comparison of Sandimmune and Neoral versus Sang-35 cyclosporine in kidney transplant recipients

Other drug-associated ARF

c Amiodarone, a forgotten nephrotoxic?

Hemolytic/uremic syndrome and TTP

c Familial hemolytic uremic syndrome (HUS).
c Long-term prognosis of children with severe diarrhea-associated (D+) hemolytic uremic syndrome (HUS): Comparison of patients in high versus low incidence areas

Acute interstitial nephritis/NSAID

c HIV protease inhibitor associated nephritis

Papillary necrosis

c Fifteen year follow-up of reflux nephropathy (RN) by radiological imaging

Hereditary polycystic disease

c Phenotype PKD2 vs PKD1; results from the European concerted action.
c Autosomal dominant polycystic kidney disease (ADPKD) in African Americans: Prevalence and clinical course.
c Polycystin expression in PKD-1, infantile PKD-1 and TSC-2/PKD-1 cystic kidney: Evidence against a two-hit disease mechanism in cyst initiation.

Creatinine clearance

c Prediction of decline in GFR from estimated creatinine clearance in chronic renal failure

Fanconi syndrome

c Dent's like proximal renal tubular disorder in a First Nations' kindred.


c Indirect evidence to suggest that hyponatremia by itself cotributes to the high urate clearance in the SIADH
c Saline infusion is useful in most SIADH patients and the increase in plasma sodium is related to urinary osmolality and not to urinary sodium and potassium loss

Treatment (CEI, indomethacin, lipid drugs)

c Does albumin enhance the diuretic action of furosemide in nephrotic syndrome?
c Efficacy and safety of recombinant human serum albumin in refractory edema accompanying nephrotic syndrome

Metabolic acidosis

c Fanconi's syndrome: an Acadian variant
c Lactic acidosis induced by stavudine (d4T)
c Autoantibody to carbonic anhydrase II may be responsible for pathogenesis of renal tubular acidosis in Sjogren's syndrome
c A heterozygous missense mutation in the AEI CT/HCO3 exchanger gene cosegregates with autosomal dominant distal renal tubular acidosis (dRTA) in two unrelated families.
c Mutations in the chloride-bicarbonate exchanger gene AEI in autosomal dominant but not autosomal recessive distal renal tubular acidosis.

Metabolic alkalosis

c Renal tubular alkalosis with chronic hyperkalemia

Renal biopsy techniques, tips, complications

c Outpatient percutaneous renal biopsy in high risk patients
c The clinical efficacy of transjugular renal biopsy.
c Slide platelet aggregation time (SPAT) does not correlate with bleeding time (BT) in patients with renal failure undergoing biopsy.

Diagnostic approach to hematuria

c The comparison of the urine RBC phase contrast microscopy and immuoperoxidase stain in differentiation of renal and nonrenal hematuria
c Nut-cracker syndromes: As one cause of unknown origin hematuria to nephrologists in spite of studies for hematuria

Diagnostic approach to proteinuria

c Simplified screening for microalbuminuria
c Proteinuria in atheroembolic disease

Cryoglobulinemia not due to hepatitis

c A peculiar type of interstitial infiltrates in cryoglobulinemia glomerulonephritis (CryoGN).


c Predictors of microalbuminuria in individuals with insulin dependent diabetes mellitus (DDM). An update
c Threshold effect of hyperglycemia on the progression of microalbuminuria in type I diabetes
c Successful pancreas transplantation (PT) alone reverses established lesions of diabetic nephropathy (D) in man
c Preservation of normal GFR with long-term captopril treatment in normotensive IDDM patients with microalbuminuria
c Initial decrease in proteinuria after institution of ACE inhibitor treatment predicts long term prognosis for kidney function in overt diabetic nephropathy
c Long-term follow up of the eight patients with diabetic nephropathy who experienced remission of nephrotic syndrome during the captopril study
c Effects of pyridoxamine, a novel post-Amadori AGE inhibitor, on nephropathy induced by glycated albumin.

Focal, collapsing GN

c Therapy of FSGS with nephrotic syndrome--3 years follow up of a prospective randomised multicenter study
c Glomerular tip lesion (GLT): clinical features, response to corticosteroids and comparison to focal segmental glomerulosclerosis (FSGS)
c Detection of parvovirus B19 DNA in renal biopsies of patients with idiopathic collapsing glomerulopathy

IgA Nephropathy

c Long-term treatment with fish oil reduces renal progressionn in patients with IgA nephropathy (IgAN)
c Two year steroid therapy in progressive IgA nephropathy--A prospective, controlled 10-year follow-up study

Hereditary hematuria/proteinuria

c Outcome of renal transplantation in patients with Alport's syndrome (AS).

Lupus nephritis

c The prevalences and clinical characteristics of ANCAs in lupus nephritis
c Activity of lupus nephritis as related to serum levels of soluble Fas
c Mycophenolate mofetil therapy in patients with cyclophosphamide-(CyP) resistant or relapsing diffuse proliferative lupus nephritis (SLE- DPGN)

Vasculitis (Wegener's PAN, etc.)

c Cyclosporine for the prevention of relapses in ANCA-associated vasculitits
c Mycophenolate mofetil is effective for maintenance therapy of systemic vasculitis

Renal Stones: Diagnosis

c Low gastrointestial absorption of alkali as a cause of idiopathic hypocitraturia

Renal Stones: Etiology

c Reduced bone mass in asymptomatic mothers and their children with idiopathic hypercalciuria (IH).
c Age-related variations in urine chemistry risk factors for kidney stone formation.

Renal Stones: Treatment

c Enalapril causes low urinary citrate excretion in normal human volunteers.
c Beverage use and the risk of kidney stones in women
c Intake of vitamins B6 and C and risk of kidney stones in women


c Reversal of adynamic bone disease after successful renal transplantation.
c Effect of oral potassium citrate on urinary excretion of aluminum after renal transplantation.
c Intermittent oral calcitriol and intravenous pamidronate in renal allograft recipients: Divergent effects on bone metabolism and parathyroid function.
c A controlled, comparative study of two regimens (750 mg bid and 500 mg bid) of oral ganciclovir in the prevention of cytomegalovirus infection in post-kidney transplant "CMV at risk" rec
c Renal thrombotic microangiopathy associated with anticardiolipin antibodies in hepatitis C positive renal allograft recipients
c Vascular and interstitial features of cellular renal allograft rejection: Effects on therapy and outcome
c The association of chronic kidney graft failure with recipient blood pressure.
c Should eosinophilia be included in the Banff classification of renal allograft rejection?
c Ganciclovir (G) pharmacokinetics in renal transplant patients (RTR) with cytomegalovirus (CMV) infection.
c Thymoglobulin reverses refractory acute rejection in kidney transplant recipients.
c Predictors for the recurrence of IgA disease following renal transplantation.

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