Long-term prognosis of children with severe diarrhea-associated (D+) hemolytic uremic syndrome (HUS): Comparison of patients in high versus low incidence areas
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:148A 1997
This series of children with severe HUS (required dialysis) provides further evidence for longterm sequelae in a the majority of survivors, in particular chronic renal insufficiency, proteinuria and hypertension. Of 72 patients who ere followed for at least 30 months post-HUS (range 2.5 to 20 years), 33% wound up with GFR < 90 ml/min/1.73 m2, 21% had proteinuria and/or hypertension (GFR normal or unkown), 15% either died or were on dialysis, and 30% had a complete recovery.
Comment: The large sample size allows more confident estimates of the rates of these complications. Prognostic indicators were CNS disease, duration of anuria and persistent proteinuria and hypertension, as has been shown in other studies. The distinction made between patients in areas of high incidence and low incidence is hard to interpret with the limited information provided. (Susan Mendley, M.D., Northwestern University, Chicago, IL)
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ASN 30th Annual Meeting, San Antonio
ARF etiology : Hemolytic/uremic syndrome and TTP