Dialysate side Kt/V -- a whole body approach
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:292A 1997
This abstract describes an approach for calculating whole body or equilibrated urea Kt/V that is based on continuous measurement of dialysate urea concentration. The rate of decrease in dialysate urea concentration is used to calculate the urea removal rate with respect to the mean body urea concentration. This approach was validated in vitro and compared with equilibrated Kt/V calculated using blood urea nitrogen concentrations. Agreement between the described approach for calculating whole body Kt/V and equilibrated Kt/V was excellent.
Comment: This approach for calculating whole body or equilibrated urea Kt/V appears to be similar to that previously described by Keshaviah et al (Pediatr Nephrol 9:S2-S8, 1995) and by Garred (Adv Ren Repl Ther 2:305, 1995) since the decrease in dialysate urea concentration is used to assess the rate of urea removal. The authors claim that their approach is model independent, but this claim is not easy to assess from an abstract. If this approach is truly model independent, then it represents a major advance since it has been difficult to determine the best model for describing urea sequestration during hemodialysis. In any case, the described model accurately determines whole body urea Kt/V without the need for obtaining blood samples. (Ken Leypoldt, Ph.D., University of Utah Health Sciences Center, Salt Lake City, UT)
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ASN 30th Annual Meeting, San Antonio
Basic hemodialysis : Adequacy, prescription, urea kinetics