Familial hemolytic uremic syndrome (HUS).
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:130A 1997
Non-concurrent familial HUS is usually considered to have a different etiology and prognosis from epidemic or diarrheal HUS which affects multiple family members. However, authors from a large center with wide experience treating diarrheal HUS draw attention to 3 families in which siblings or cousins developed diarrheal HUS separated by > 2 years. Their course and outcome suggest an etiology similar to other cases of diarrheal HUS. In the experience of this center, non-concurrent diarrheal HUS is more common than familial HUS.
Comment: This report makes several interesting observations. First, as the incidence of diarrheal HUS increases (perhaps as a result of a greater prevalence of E. Coli O157:H7), non-concurrent cases in a family will be less likely to represent an hereditary, relapsing, non-diarrheal form of HUS. Such an observation counters previously held notions about distinguishing between these two distinct forms of HUS. Second, there is likely a genetic predisposition which explains why only a small minority of patients with enteric infection with verotoxin-producing organisms develop HUS. These families provide a window into that predisposition. (Susan Mendley, M.D., Northwestern University, Chicago, IL)
To go back use the BACK button on your browser. Otherwise click on the desired link to this article below:
ASN 30th Annual Meeting, San Antonio
ARF etiology : Hemolytic/uremic syndrome and TTP
Proteinuria/Hematuria : Hereditary hematuria/proteinuria