Glomerular tip lesion (GLT): clinical features, response to corticosteroids and comparison to focal segmental glomerulosclerosis (FSGS)
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:87A 1997
This is a timely abstract that deals with the important lesion of glomerular tip lesion and asks whether it is different from the focal sclerosis in terms of clinicla features and response to steroids. the strength of the abstract is the large number of patients with the GTL and their data is well defined with a decent follow-up interval. The authors show that patients with GTL are more likely to be white and have a more pronounced nephrotic syndrome,i.e., more proteinuria, more severe hypoalbuminemia and hypercholesterolemia. Although the authors describe a nearly 80% response to steroids compared to 33% of patients with focal sclerosis, the response was rather generously defined - aa reduction in proteinuria of 50%. Considering that the mean proteinuria was 12.8 g/day a 50% reduction would still put them in the nephrotic range. It certainly appears that steroids do reduce the severity of nephrosis in these patients. However, the renal survival at 4 years was not different between the two lesions. (B.S. Kasinath, M.D., University of Texas at San Antonio)
To go back use the BACK button on your browser. Otherwise click on the desired link to this article below:
ASN 30th Annual Meeting, San Antonio
Proteinuria/Hematuria : Focal, collapsing GN