Acute effects of high dose furosemide on residual renal function in CAPD patients.
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Oct) 8:293A 1997
This study investigated the effect of high dose (2000 mg) furosemide on urine volume, electrolyte excretion, and renal function. 8 CAPD patients were studied, with inulin clearances 0.6-13.8 ml/min, median 3.0, and residual urine outputs 140-2700 ml/24h. 2 clearance period were studied: a baseline and during the 2 g furosemide dose. GFR was unchanged by furosemide, but volume increased by 270-910 ml (median 500), and FE Na and FE K increased. Variability in response was attributed to level of residual renal function.
Comment: That furosemide retains diuretic and natriuretic effect in ESRD patient with some residual function is well known, as is the fact that, despite a diuretic response, renal function, i.e. GFR, is not improved. The abstract leaves me with several questions: how was inulin clearance done, was furosemide given p.o. or by i.v. infusion, why was median GFR reported as 3.0 ml/min in the introduction, then reported as unchanged at 4.3 vs. 4.1 ml/min later on? Studies are needed to determine the safety and sustained efficacy of high dose Lasix in selected ESRD patients who have residual renal function. (James A. Sondheimer MD, Wayne State University, Detroit, MI)
To go back use the BACK button on your browser. Otherwise click on the desired link to this article below:
ASN 30th Annual Meeting, San Antonio
CRF by organ system : Cardiovascular/Hypertension
Basic hemodialysis : Complications (acute)