Outcome of renal transplantation in patients with Alport's syndrome (AS).
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:670A 1997
The investigators performed a case controlled retrospective study of the outcome of renal transplantation in patients with Alport's syndrome (AS). The study involved review of patients transplanted at the University of Wisconsin. Forty-six patients (1.8%) of 2606 patients transplanted had AS. Compared to a control group of 1828 non-diabetic patients the patients with AS were significantly younger and more male. There was no difference in graft survival in the patients with AS. One, 5 and 10 year graft survival in the AS patients was 81.9%, 74.8%, and 55.7% compared to 80.6%, 67.3%, and 52.3% in the control group. There was also no difference in age adjusted patient survival. Only 5 patients had biopsy proven antiglomerular basement membrane antibody. Of the 21 grafts lost, 2 were lost secondary to antiglomerular basement membrane antibody (10%).
Comment: Patients with AS are at risk for developing antiglomerular basement membrane antibody. This retrospective study of 46 patients showed no difference in graft or patient survival after transplantation compared to case matched controls. In addition antiglomerular basement membrane antibody occurred rarely. The true incidence of antiglomerular basement membrane antibody is unknown since this was a retrospective study. However, antiglomerular basement membrane antibody rarely led to graft loss. (Rosemary Ouseph, M.D., University of Louisville, KY)
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ASN 30th Annual Meeting, San Antonio
Proteinuria/Hematuria : Hereditary hematuria/proteinuria
Transplant : Transplantation