Reduced bone mass in asymptomatic mothers and their children with idiopathic hypercalciuria (IH).
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:551A 1997
The authors measured bone mineral density (BMD) by DEXA in 21 children with IH (age 9 ± 4yrs), and their non-stone-forming premenopausal mothers (40 ± 5 yrs). 38% of children, and 33% of mothers had reduced BMD at lumbar spine and /or femoral sites (as compared to age and gender-matched controls). Z scores were concordant in 57% of all mother-child pairs. 74% (14/19) of mothers had hypercalciuria and 86% (6/7) of those with reduced BMD had hypercalciuria. There was no correlation between reduced BMD and urinary calcium excretion.
Comment: The results demonstrate the early age of onset on the well described lower BMD seen in patients with hypercalciuria and, presumably, stone formation. Interestingly, there was a high incidence in unsuspected reduced BMD and hypercalciuria in their mothers as well. Since the mothers were not stone formers, a similar evaluation of the fathers would have been revealing. Since women are at lower risk for stones (for somewhat obscure reasons) the concordance of reduced BMD and stone formation might have demonstrated important data regarding the inheritance of the traits of hypercalciuria, low BMD and stone disease. (David S. Goldfarb, M.D., NYU School of Medicine)
To go back use the BACK button on your browser. Otherwise click on the desired link to this article below:
ASN 30th Annual Meeting, San Antonio
Nephrolithiasis : Renal Stones: Etiology
H: Special problems : Hypercalciuria