Lactic acidosis induced by stavudine (d4T)
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:105A 1997
Chronic lactic acidosis is a side effect of zidovudine (AZT) inhibition of mitochondrial DNA polymerase. Mokrzycki and colleagues report 3 cases of lactic acidosis induced by stavudine (d4T), a more potent inhibitor of mitochondrial DNA polymerase than AZT.
Comment: These are the first documented cases of lactic acidosis associated with d4T. Toxicity of nucleoside analogues should be considered in the differential diagnosis of lactic acidosis in HIV infected patients treated with these agents. (George R. Aronoff, M.D., University of Louisville, Kentucky)
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ASN 30th Annual Meeting, San Antonio
Acidosis/alkalosis : Metabolic acidosis
Proteinuria/Hematuria : HIV-associated nephropathy