Possible neurologic effects of fentanyl in dialysis patients
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:229A 1997
Neurotoxicity of meperidine from accumulation of its demethyl metabolite normeperidine is well known in patients with renal failure unable to excrete this polar metabolite. Similar toxicity has been reported from the accumulation of morphine metabolites in renal failure. Byrns and colleagues report four elderly dialysis patients who developed similar neurotoxicity after receiving the meperidine congener, Fentanyl.
Comment: Since norfentanyl is a metabolite of Fentanyl, it is likely that the neurotoxicity observed in these patients was caused by accumulation of this metabolite. This important case report reminds us that our dialysis patients should not receive large doses of Fentanyl and that alternate anesthesia should be considered. (George R. Aronoff, M.D., University of Louisville, Kentucky)
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ASN 30th Annual Meeting, San Antonio
CRF by problem area : Drug use in CRF
CRF by organ system : Neurological