Experimental evidence for strontium (Sr) to play a role in the development of dialysis related osteomalacia (OM).
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:555A 1997
The authors previously reported increased bone Sr levels in dialysis patients with osteomalacia. To determine if Sr could play a causal role in osteomalacia, Sr was added to the drinking water of uremic rats for 12 weeks and bone histology was compared to uremic rats not receiving Sr. The bone of rats receiving Sr developed osteomalacia. Sr was present in calcified bone of both trabeculae and cortex, mainly at the osteoid calcified bone boundary. Sr may play a causative role in the development of osteomalacia in hemodialysis patients.
Comment: It is unclear to me how much Sr the rats actually received; i.e., a lot or a little. Perhaps a better control would be another metal given in the same amount. (James A. Delmez, M.D., Washington University, St. Louis)
To go back use the BACK button on your browser. Otherwise click on the desired link to this article below:
ASN 30th Annual Meeting, San Antonio
CRF by problem area : Bone disease/aluminum