Parenteral iron causes increased lipid peroxidation in hemodialysis patients.
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Oct) 8:251A 1997
As interest in the use of iv iron has gained popularity in recent years, an appropriate examination of potential long term consequences is important. Of the many functions of iron, one is to facilitate the formation of reactive oxygen species, with resultant lipid peroxidation, via the Haber-Weiss reaction. The purpose of this study was to examine whether this may occur with iv iron therapy. Eight patients treated with either iron dextran or iron saccharate were studied. Oxidation products increased significantly, but to a small degree with both agents.
Comment: There are several areas of safety with regard to iv iron use which require careful study as iv iron use is increasingly utilized in dialysis patients. Vascular toxicity related to the induction of reactive oxygen species is certainly one important area. This study demonstrates that this an issue that requires further study. However, the magnitude of effect was so small as to question whether there is any clinical significance. (Stephen Fishbane, M.D., Winthrop University Hospital, Mineola, NY)
To go back use the BACK button on your browser. Otherwise click on the desired link to this article below:
ASN 30th Annual Meeting, San Antonio
CRF by problem area : Anemia/Erythropoietin/Iron
CRF by organ system : Cardiovascular/Hypertension