Cyclosporine (CsA)-induced nephrotoxicity (NT) in auto-immune diseases (AID): A meta-analysis.
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:149A 1997
Treatment of autoimmune diseases with cyclosporine was compared to other therapies using a meta-analysis. The authors conclude that patients treated with cyclosporine are at increased risk of developing nephrotoxicity.
Comment: In this meta-analysis 423 studies were screened, but only 18 were selected for final analysis. All non-cyclosporine treatments were combined regardless of relative nephrotoxicity and regard for the severity of the autoimmune disease as a reason for choosing cyclosporine or other treatments were not considered. The authors make the important point that treatment with cyclosporine is not without risk. However, interpretation of meta-analyses must be tempered with the knowledge of possible confounding variables or study bias in selection of included papers and analysis. (George R. Aronoff, M.D., University of Louisville, Kentucky)
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ASN 30th Annual Meeting, San Antonio
ARF etiology : Cyclosporine, ARF in transplant patients
Nephrotic Syndrome : Treatment (CEI, indomethacin, lipid drugs)