Proteinuria in atheroembolic disease
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:97A 1997
Atheroembolic renal disease (AERD) has been associated with nephrotic syndrome and FSGS. 34 specimens obtained over an 8- year period with histologically-proven AERD were reviewed. Prior vascular intervention occurred in 32/34 patients. Dipstick proteinuria was noted in 5/34; 1-3.5 g/24h in 6/34, and > 3.5 g/24h in 5/34. Patients with nephrotic range proteinuria has more global sclerosis in the glomeruli; however, the FSGS pattern was uncommon. The authors conclude that substantial proteinuria is not uncommon in AERD.
Comment: This is a fairly large series of cases and clearly demonstrates that the presence of substantial and even massive proteinuria does not exclude the diagnosis of AERD, especially where there is a high clinical suspicion for this disease (progressive renal insufficiency associated with livedo reticularis, mottled/cyanotic toes, eosinophilia, recent aortic instrumentation). (David J. Leehey, M.D., Loyola University at Chicago)
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ASN 30th Annual Meeting, San Antonio
Proteinuria/Hematuria : Diagnostic approach to proteinuria
ARF etiology : Embolic disease