Downregulation of osteoblast PTH/PTHrP receptor mRMA expression in renal failure.
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:554A 1997
There are many studied suggesting a blunting of the bone response to PTH in uremia. The authors used in situ hybridization to examine PTH/PTHrP receptor mRNA expression by osteoblasts in human bone. High bone turnover uremic patients were compared to high bone turnover patients with normal renal function and to normal controls. The mean density of the receptor signal in uremic subjects was only 39% of that of non-renal high bone turnover patients and 50% of that found in normal bone. In addition, localized signal was seen over actively resorbing osteoclasts. There appears to be downregulation of the PTH/PTHrP receptor at the level of transcription in renal failure.
Comment: An interesting finding assuming the methodology is rigorous. The change in mRNA may or may not be reflected in a decrease in actual receptor density. (James A. Delmez, M.D., Washington University, St. Louis)
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ASN 30th Annual Meeting, San Antonio
CRF by problem area : Bone disease/aluminum