Effect of lactate or bicarbonate buffered CAPD solutions on netilmycin bactericidal activity/
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:176A 1997
Bicarbonate buffered CAPD solutions may prevent bacterial peritonitis due to their improved biocompatibility compared to lactate based solution. This study compared the growth of E. coli in lactate and bicarbonate solutions containing 1.5% or 4.25% glucose and in the presence of netilmycin. Netilmycin had a lower LD50 for E.coli in bicarbonate solutions compared to lactate at both concentrations of glucose.
Comment: This study shows that the antibacterial activity of netilmycin is enhanced in bicarbonate solutions, but the effectiveness of other antibiotics needs to be studied to demonstrate that they are compatible with bicarbonate containing solutions. (George R. Aronoff, M.D., University of Louisville, Kentucky)
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ASN 30th Annual Meeting, San Antonio
Basic peritoneal dialysis : Peritonitis and exit-site infection
Basic peritoneal dialysis : PD solutions, equipment