Higher levels of antioxidant defenses in chronic renal patients in hemodialysis treated with ACEi.
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:218A 1997
Having demonstrated antioxidant enhancing effects of ACEI in normal mice, the authors investigated the effects of ACEI in hemodialysis patients, a group which has been identified as having impairments in antioxidant defenses. 11 HD patients receiving 15 mg/d enalapril for 6 months were compared with 11 age/sex matched HD controls, and were analyzed for: RBC superoxide dismutase, glutathione peroxidase, catalase, glutathione; and plasma alpha-tocopherol, beta-carotene, ubiquinol-10. Significant increases were shown in glutathione, glutathione peroxidase, and superoxide dismutase.
Comment: There is increasing interest in both the scientific and the lay media in the whole topic of the health effects of anti-oxidant substances. The phenomenon of decreased antioxidant activity in ESRD has been described, and this report of interest for showing a mitigating factor, i.e., ACE inhibition. Future studies will be needed to determine the significance of this , as well as to answer whether all ACEI agents are alike in this regard. The study would have benefited from another control group, viz., normals without renal disease (or anti-oxidant vitamins). (James A. Sondheimer MD, Wayne State University, Detroit, MI)
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ASN 30th Annual Meeting, San Antonio
CRF by organ system : Cardiovascular/Hypertension
H: Drug therapy : ACE inhibitors