Autoantibody to carbonic anhydrase II may be responsible for pathogenesis of renal tubular acidosis in Sjogren's syndrome
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:107A 1997
Synopsis: Distal RTA is a complication of Sjögren's syndrome (SS). 159 patients with SS and 43 control volunteers were examined for serum antibodies to CAII. Patient titers were 0.66 ± 0.33 units vs 0.51 ± 0.21 in controls (p <0.01). Patients with high titers (n=7) had abnormal urinary acidification. Serum from SS patients showed staining of the cytoplasm of intercalated cells by immunofluorescence.
Comment: Autoantibodies reactive with carbonic anhydrase were found previously in sera from patients with systemic lupus erythematosus and Sjogren's syndrome (J Dermatol Sci. 3: 147-154, 1991), and it was suggested that they might have a role in the distal RTA of SS. The present study has examined a larger group of patients, and has examined formally for acidification defects. Unfortunately, the specificity of the serum CAII reactivity was not examined (for example by Western blot on kidney extract with and without CAII preabsorption). The difference in titers between patients and controls is not impressive, and may represent a non-specific hypergammaglobulinemia. It is also unclear how antibodies to an intracellular protein would produce distal RTA. (Stephen L. Gluck MD, Washington University School of Medicine, St. Louis, MO)
To go back use the BACK button on your browser. Otherwise click on the desired link to this article below:
ASN 30th Annual Meeting, San Antonio
Acidosis/alkalosis : Metabolic acidosis