Overestimation of blood glucose measurements by auto-analyser method in CAPD patients (pts) treated with icodextrin.
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:275A 1997
This study reports the interference of icodextrin metabolites in serum (principally maltose) with the "glucose dehydrogenase" laboratory blood glucose assay. In six CAPD patients treated with icodextrin for at least seven consecutive days, blood glucose with the dehydrogenase method was 165 ± 32 mg/dL, with the oxydase method 96 ±20 mg/dL and with the hexokinase method 100 ± 15 mg/dL. Overestimation was not observed in patients not treated with icodextrin. This overestimation can mask true hypoglycemia in insulin-treated diabetic patients.
Comment: After a long study period glucose polymers (icodextrin) are now in clinical use. This study points out a particular interference problem linked with high maltose levels in serum due to icodextrin reabsorption and hydrolysis. Serum glucose overestimation, present only with the "glucose dehydrogenase" method, may not only mask true hypoglycemia in insulin-treated diabetics but also determines false hyperglycemia in normoglycemic and diabetic patients. (Gianpaolo Amici, M.D., Treviso, Italy).
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ASN 30th Annual Meeting, San Antonio
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