Preservation of normal GFR with long-term captopril treatment in normotensive IDDM patients with microalbuminuria
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:115A 1997
The goal of this study was to determine the long term efficacy of ACE inhibition on GFR in microalbuminuric IDDM patients. 44 normotensive IDDM patients with persistent microalbuminuria (urinary albumine excretion [UAE] 30-300 mg/24h) were randomized to treatment with captopril (50 mg bid) plus thiazide or no treatment (unless hypertension developed) and were followed for 8 years. 9/23 (40%) of control patients but only 2/21 (10%) of treated patients progressed to overt nephropathy. GFR decreased 12.2 ml/min in the control group but only 1.4 ml/min in the captopril group (p=0.06). The authors conclude that ACE inhibition has long-term beneficial effects in normotensive microalbuminuric IDDM patients.
Comment: These data are further evidence that patients with IDDM (and indeed all diabetic patients) with microalbuminuria should be treated with ACE inhibitors. (David J. Leehey, M.D., Loyola University at Chicago)
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ASN 30th Annual Meeting, San Antonio
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