Therapy of FSGS with nephrotic syndrome--3 years follow up of a prospective randomised multicenter study
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:87A 1997
The treatment of idiopathic FSGS is still a controversial issue with a conspicuous lack of controlled studies. The authors compared the response of 23 patients treated with steroids and cyclosporine with 24 patients given steroids and chlorambucil. All the patients in the second group were refractory to chlorambucil in terms of proteinuria and serum creatinine and were given cyclosporine. The details of the regimens were not given. At the end of 3 yrs of followup the renal function in the cyclosporine group was marginally better (? statistical significance) and proteinuria decreased by nearly 50%. The authors conclude that chlorambucil was not of benefit in FSGS and that cyclosporine may be superior.
Comment: The value of cyclosporine is debatable as there was no steroids alone group. Anecdotal reports claim that up to 30% of patients may respond to steroids alone. Additionally, whether cyclosporine could be stopped without relapse of proteinuria and worsening of renal function is unclear. (B.S. Kasinath, M.D., University of Texas at San Antonio)
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ASN 30th Annual Meeting, San Antonio
Proteinuria/Hematuria : Focal, collapsing GN