Age-related variations in urine chemistry risk factors for kidney stone formation.
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:561A 1997
Whether age plays a role in the development of kidney stones was evaluated by determining urinary chemistries and supersaturations for calcium oxalate, calcium phosphate, and uric acid in 2377 stone-formers. Measurements were performed on triplicate samples prior to therapy. Patients were stratified by age (greater than 60 yrs) and sex. Both the older males and females had significantly lower supersaturations of calcium oxalate and calcium phosphate, whereas there was no differences in the supersaturation of uric acid, urinary citrate and urinary volume.
Comment: Much data has accumulated regarding risks for recurrent stone formation. Urinary volume, supersaturations for calcium oxalate, calcium phosphate, and uric acid and the presence of inhibitors of stone formation and growth (citrate) are important predictors of recurrent stone formation. That older stone formers had lower SS of calcium oxalate and phosphate with similar urinary volumes and citrate suggests that other factors may play a role in stone formation in older patients. Additional epidemiological and prospective studies are required to further elucidate what changes occur with aging that may facilitate stone formation. (Stuart Sprague, D.O., Northwestern University, Chicago, IL)
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ASN 30th Annual Meeting, San Antonio
Nephrolithiasis : Renal Stones: Etiology