Diagnosis of cardiac injury in renal disease patients: Value of cardiac troponins.
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:144A 1997
Cardiac troponins have been proposed as a marker for cardiac injury, reportedly with greater specificity than the "classic" MB-CPK. The authors studied 21 HD patients, 20 CRF pts (mean CCr 13.4 cc/min), but no normal renal function controls. These patients were free of cardiac symptoms for 2 weeks prior to assay for CPK, CPK-MB, myoglobin, and cardiac troponins T and I, the latter measured by 3 different assays (generation not specified). Although several of these measures were elevated in HD pts, none predicted cardiac outcome in 6 months follow-up.
Comment: The problem with using cardiac troponins in CRF/ESRD patients has been well established in the recent literature; it seems that higher-generation tests may yet result in a troponin test of predictive utility in CRF. See Clin Chem 43(6 Pt 1):976-982, 1997; Clin Chem 43:458-466, 1997; Am J Kidney Diseases 29:399-403, 1997. (James A. Sondheimer MD, Wayne State University, Detroit, MI)
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ASN 30th Annual Meeting, San Antonio
CRF by organ system : Cardiovascular/Hypertension