Beneficial effect of ace inhibition on survival of patients with renovascular hypertension (RVH).
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:142A 1997
The aim of this study was to analyze risk factors for mortality in patients with renovascular hypertension (RVH) enrolled in a prospective follow-up study. 64 RVH patients with mean renal artery stenosis of 78% were followed for an average of 38 months. Cumulative survival at 50 months was 60%. Using a Cox proportional hazards model, survival was enhanced by treatment with ACE inhibitors despite comparable blood pressures and serum creatinines in the treated and untreated groups. However, the untreated group was older than the treated group. The authors conclude that treatment with ACE inhibitors decreases mortality in RVH patients.
Comment: ACE inhibitors can be "double-edged swords" in RVH because they can decrease renal function in kidneys with hemodynamically significant stenosis. These data support the use of ACE inhibitors in this population, but the results are tempered by differences in patient age between the two groups. (David J. Leehey, M.D., Loyola University at Chicago)
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ASN 30th Annual Meeting, San Antonio
H: Special problems : Renovascular hypertension
H: Special problems : Outcomes