Pharmacokinetics of quinupristin/dalfopristin (Syndercid RP 59500) in patients receiving continuous ambulatory peritoneal dialysis (CAPD).
ASN 30th Annual Meeting, San Antonio
J Am Soc Nephrol (Sep) 8:264A 1997
Quinupristin/dalfopristin is an antibiotic combination that may be useful for treatment of vancomycin-resistant enterococci. Johnson and colleagues measured the pharmacokinetics of the combination in CAPD patients after a single intravenous dose. They found the kinetics of the parent compounds and a metabolite unaltered in patients on CAPD and that very little drug appeared in the peritoneal fluid.
Comment: It is useful to document the kinetics of the drug during CAPD, but a more complete study would have included the intraperitoneal administration of the compounds. From the current study, the drug combination should not be used to treat ambulatory peritonitis, because of the very low levels observed in the peritoneal fluid. (George R. Aronoff, M.D., University of Louisville, Kentucky)
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ASN 30th Annual Meeting, San Antonio
CRF by problem area : Infections (other than hepatitis, peritonitis)