Acchiardo SR, Moore L, Smith SO, Burk LB, Smith SJ, Will K
Increased dialysis prescription improved nutrition
Am Soc Nephrol
J Am Soc Nephrol (abstract) (Nov) 6:571 1995

There continues to be controversy as to whether Kt/V and PCRn are linked in a causal or artefactual fashion. Acchiardo et al followed 130 dialysis patients in whom he increased Kt/V from 1.0 to 1.2. The PCRn improved concomitantly, and the improvement was highest in patients with lower baseline PCRn values. The serum cholesterol also increased, as did the serum albumin. The increases in albumin were most marked in patients with low initial serum albumin values.

Comment: These results certainly cannot be explained by any type of statistical artefact and suggest that indeed increasing dialysis Kt/V does improve nutritional status. (Daugirdas)

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Am Soc Nephrol
CRF by organ system : Nutrition
Basic hemodialysis : Adequacy, prescription, urea kinetics