Allen DA, Macdougall IC, Raine AEG
Interferon-gamma mediates resistance to erythropoietin
in uremic patients with inflammatory disease
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:517 1995
Acute or chronic inflammation is clearly an important cause of resistance to
EPO therapy. This study examined mechanisms of this effect. Serum from
EPO-resistant patients was incubated with or without anti-interferon gamma
antibodies and exposed to rabbit erythroid cells. Erythroid colony forming
units were scored after 7 days. Serum from HD patients with inflammatory
disease had the greatest negative impact on erythropoiesis. This effect was
greatly attenuated by the addition of antibodies against interferon
gamma.
Comment: Very interesting study which provides evidence supporting the
role
of interferon gamma in mediating EPO resistance in HD patients with
inflammation. A potential clinical implication may be in a possible
relationship between biocompatibility of HD membranes (and relative
differences in interferon induction) with EPO resistance.
(Fishbane)
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Am Soc Nephrol
CRF by problem area :
Anemia/Erythropoietin/Iron