Almaden Y, Hernandez A, Torregrossa V, Campistol J, Torres A,
Rodriguez M
High phosphorus directly simulates PTH secretion by
human parathyroid tissue
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:957 1995
Slices of human parathyroid glands removed from patients with secondary
hyperparathyroidism
were incubated in media with high (4 mM) or low (1 mM) phosphorus. In all,
the 4 mM solution increased PTH secretion. In 2 glands studied, high P
increased the mRNA for PTH. The high P media also prevented the suppression
of PTH by high Ca concentrations in the media.
Comment: Similar results have been reported by Silver and co-
workers and Slatopolsky
and co-workers in rats. The trade-off hypothesis takes another turn. This is
further evidence that high serum phosphorus levels may per se stimulate PTH
secretion.
(Fishbane)
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