Barth RH, Aboul-Magd A, Goldwasser P
Response to iron dextran therapy is not precluded by high
serum ferritin Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:519 1995
Serum ferritin is often elevated by factors independent of iron stores,
leading to underdiagnosis of suboptimal iron stores in hemodialysis
patients.
In this study a course of IV iron was administered to HD patients with
varying levels of serum ferritin. The primary finding was that a positive
response to IV iron could be obtained in patients with TSAT less than 15%
with serum ferritins as high as 600 ng/ml.
Comment: This confirms the poor sensitivity of the serum ferritin
for
defining inadequate iron stores in hemodialysis patients. An undefined issue
would be the safety of administering IV iron to patients with relatively
high
serum ferritins given the link between cardiovascular risk and the serum
ferritin concentration.
(Fishbane)
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