Bataille P, Hardy P, Marie A, Steiniche I, Cohen-Solal ME,
Brazier M, Westeel A, Fournier A
Decreased bone formation in idiopathic hypercalciuric
calcium stone formers explains reduced bone density
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:933 1995
Bone biopsies were done in 24 patients with diet independent idiopathic
hypercalciuria and low
vertebral density and compared to controls. The patients showed evidence of
lower bone
formation and not excess bone resorption. They also had lower levels of PTH
and higher levels of
calcitriol.
Comment: A challenge to the usual notion that
these patients have a primary problem
with excess bone resorption.
(Delmez)
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