Bergstrom J, Heimburger O, Lindholm B, Qureshi AR
Elevated serum C-reactive protein is a strong predictor of
increased mortality and low serum albumin in hemodialysis
patients
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:573 1995
In 128 patients followed for 4 years, C-reactive protein correlated
inversely with serum albumin and was a better predictor of survival at one
year than albumin. A Cox proportional hazard model showed that C-reactive
protein was an independent predictor of survival whereas albumin lost its
significance when corrected for C-reactive protein and other variables.
Comment: This is a remarkable long-term study of patients categorized
according to their C-reactive protein and albumin levels. Since C-reactive
protein is an acute phase protein and albumin is a negative acute phase
protein, the antiparallel correlation between mortality and the serum
concentration of these two liver-derived proteins suggests that and
inflammatory process or something other than nutritional deficiency is
responsible for the high mortality associated with low albumin
concentrations in ESRD patients.
(Depner)
To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
Am Soc Nephrol
CRF by organ system :
Nutrition
CRF: Problem Areas :
Outcomes (Morbidity, Mortality)