Braun N, Erley CM, Benda N, Zauner I, Kanis R, Grupp C,
Ackerman M, Heering P, Funfstuck R, Risler T
Therapy of membranous glomerulonephritis with nephrotic
syndrome. Five year follow-up of a prospective, randomized study
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:413 1995
The authors randomized 105 patients with idiopathic membranous GN to either
the Ponticelli protocol with methyl-prednisolone/chlorambucil, the deSanto
protocol with prednisone/cyclosporine or symptomatic treatment as a control
group. They found no difference in rates of remission; doubling of serum
creatinine was found in 20% of patients irrespective of treatment modality.
They conclude that cytotoxic therapy should be revised critically in the
majority of patients with MGN.
(Krane)
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Am Soc Nephrol
Proteinuria/Hematuria :
Membranous GN