Cattran D, Greenwood C, Bernstein K, Hebert L, Pohl M,
Maxwell D, Appel G, Hoy W, Faber M, Hegeman R
Results of a 6 month randomized control trial of cyclosporine
versus placebo in adults with steroid-resistant, idiopathic, focal
segmental glomerulosclerosis
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:415 1995
In a multi-center study, 48 FSGS patients unresponsive to steroids plus or
minus cytotoxic therapy for 12 weeks were randomized to 6 months of
prednisone 0.15 mg/kg plus either cyclosporine or placebo. There was an
approximately 70% induced remission in proteinuria at 6 months without a
fall in creatinine clearance in the cyclosporine treated patients compared
with placebo.
(Krane)
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Am Soc Nephrol
Proteinuria/Hematuria :
Focal, collapsing, fibrillary GN