Chertow GM, Lazarus JM, Sayegh MH, Allgren RL
Is the administration of dopamine associated with adverse outcomes in acute renal failure?
Am Soc Nephrol
J Am Soc Nephrol (abstract) (Nov) 6:460 1995

Data from a multicenter trial of the efficacy of ANP in acute renal failure were analyzed to evaluate the efficacy of dopamine. Individual investigators were permitted to use dopamine at their discretion. Surprisingly, dopamine was given to 69% of oliguric and 68% of non-oliguric patients (497 total patients). 8% had severe CHF and 30% had sepsis (conditions for which dopamine might otherwise be indicated). 21-day mortality was 31% with dopamine use, 21% without. For oliguric patients 21-day mortality was 49% with and 26% without dopamine. At 14 days more dopamine-treated patients required dialysis (47% vs 36%) regardless of ANP or placebo treatment. Therefore, dopamine was not beneficial. When the data were re-analyzed to adjust for bias in the selection of patients to receive dopamine, there was still no benefit of dopamine. Comment: Until a prospective study demonstrates a benefit for dopamine, it should not be used because of anecdotal reports of arrhythmias and paradoxical hypotension with low dose dopamine. (Paller)

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Am Soc Nephrol
Etiologic index : Reduced circulatory volume/sepsis/hepatorenal
ARF Treatment : Treatment

I am Nephrologist at Ricardo Palma Clinic in Lima-Peru. We are working with DOPAMINE in patients with Acute Renal Failure at the ICU few years ago and look good response; we use 2 - 5 microgr/Kg/min with an infusion pump. We see diuretic response: 40-50 cc/h. I wish to obtain new information about treatment, please. Thank you.
AUGUSTO SAAVEDRA
LIMA 33, PERU-Wednesday, June 11, 1997 at 21:55:04 (PDT)

in my experience dopamine not improvement and no response in acute renal failure, because the natriuretic response of tubular function is very poor at 24 hours of the inicial with dopamine i need more information about this
ivan araya (ivan@ctc-mundo.net)
santiago, chile-Monday, February 02, 1998 at 18:28:46 (PST)