Clark W, Mueller B, Kraus M, Macias W
Treatment of volume overload in patients with acute renal
failure by intermittent hemodialysis
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:485 1995
Eleven patients with ARF treated with intermittent hemodialysis (IHD) were
followed
longitudinally, and blood volume changes during their course were
analyzed to calculate total body water (V). Mean value of V was
0.65ñ0.08 of body weight, suggesting persistent volume overload as a feature
of
ARF and the inability of IHD to correct volume overload.
Comment: Although several factors may account for the continued high
proportion of body water to body weight, it appears that this is a
significant limitation of IHD because of the intermittent nature of the
procedure. This study demonstrates unequivocally that the water fraction of
body weight was essentially unchanged at the end
of IHD, providing formal evidence for what
had been suspected for a long time but never proven.
(Mehta)
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Am Soc Nephrol
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