Cockfield SM, Prieksaitis JK
Infection with hepatitis C virus increases the risk of de novo
glomerulonephritis in renal transplant recipients
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:1078 1995
This retrospective analysis of 399 renal transplant recipients who
received 434 kidneys over a 10 year period (1984 to 1994) demonstrates that
the incidence of persistent proteinuria (dip-stick 2+ or more) and de-novo
glomerulonephritis/transplant glomerulopathy in the allografts were
significantly higher (43.1% vs 26.1% with p=0.018, and 13.7% vs 4.2% with
p=0.012 respectively) in the anti-HCV positive recipients compared to
anti-HCV negative recipients. However, the incidence of recurrent GN after
transplant was no different in the two groups, as also the incidence of graft
loss, although the time to graft loss (from transplant) was longer in
anti-HCV positive individuals.
(Bhamidipati/Pereira)
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Am Soc Nephrol
Proteinuria/Hematuria :
Hepatitis-associated nephropathy
Transplant :
Transplantation