D'Haese PC, Barata JD, Pires C, Lambers LV, Simoes J, DeBroe ME
Low-dose DFO treatment (5 mg/kg) in acutely aluminum intoxicated dialysis patients using two drug administration schedules
Am Soc Nephrol
J Am Soc Nephrol (abstract) (Nov) 6:527 1995

In view of the risks of mucormycosis and ocular toxicity, the dosage recommendations for DFO have been lowered. In severely aluminum intoxicated patients, the rec. is now to give DFO 5 hours prior to dialysis, and not at the end of the previous dialysis. D'Haese et al now found that when DFO was given during the last hour of the previous dialysis, in severely intoxicated patients, serum Al levels greater than 300 ug/L and neurologic symptoms were frequent, vs absent with the new regimen (DFO 5 hours prior to high-flux dialysis). Long-term, the low dose DFO regimen was equally effective in raising PTH levels and increasing MCV, although I was a bit confused as to what the regimens being compared on a long-term (6 month basis). The authors suggest that the 5 mg/kg DFO strategy is effective, although the safety issue (e.g., mucormycosis) is still present, even with the low dose regimens. (Daugirdas)

To go back use the BACK button on your browser.
Otherwise click on the desired link to this article below:
Am Soc Nephrol
CRF by problem area : Bone disease/aluminum

---

---