Donnelly S
Hyporeninemia is associated with erythropoietin
deficiency in type I diabetic patients
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:448 1995
This study was engendered by the clinical observation that 3
patients with mild renal insufficiency and diabetes with
hyporeninemic hypoaldosteronism (HRHA) also had profound anemia
and low EPO levels. To test the hypothesis that HRHA and low EPO
levels may be linked, a chart review study was done including
type I diabetics with mild renal insufficiency. HRHA was defined
as a serum K greater than 5.5 mEq/l or hyperkalemia after therape
with ACE inhibitors. The Hgb in the presumed HRHA group averaged
10 g/dL and was substantially lower than the 12.9 g/dL in the
diabetics with more normal K levels, despite similar CrCl in the
two groups. The results suggest that renal damage in diabetics
leading to HRHA may also lead to low EPO levels, presumably
through a structural change in the kidneys.
(Daugirdas)
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Am Soc Nephrol
Acidosis/alkalosis :
Hyperkalemia
Proteinuria/Hematuria :
Diabetes