Douma CE, DeWaart DR, Struijk DG, Krediet RT
Effect of amino acid based dialysate on peritoneal blood
flow and permeability during CAPD
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:598 1995
A study of amino acid dialysate compared to dextrose, using the
theoretical construct that L-arginine in the amino acid mixture by
producing NO increases peritoneal blood flow. Using IP dextran-70 as a
volume marker the study showed increases in transcapillary
ultrafiltration (UF) rate compared to dextrose, yet total UF was no
different from dextrose since the amino acid solution also was
associated with increased lymphatic flow. IP CO2 was used to
demonstrate higher peritoneal blood flow during amino acid dwell. Mass
transfer area coefficients (MTAC) for creatinine, urea, urate, 2 M,
and 2 M were higher with amino acids, yet albumin and IgG clearance were not
increased
(Winchester)
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Am Soc Nephrol
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