Fishbane S, Maesaka J, Mitsuhashi T, Adam G, Vlassara H
In vitro clearance of advanced glycosylated end-products by
conventional and high flux hemodialysis membranes
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:488 1995
This study examined the in vitro clearance of advanced
glycosylated end products by conventional and high flux
hemodialysis. The AGE solution was formed by incubating albumin
with glucose. The membranes studied were the F8, F60, and the
AN69. Dialytic clearances of AGEs of the F60 and the AN69
membranes were twice as high as with the F8. The AN69 membrane
also showed significant adsorption of AGEs. Thus the total
clearance with the AN69 membrane was the greatest of all. The
results suggest that high flux membranes, and in particular,
AN69, may be useful in clearing AGEs from the circulation,
although the therapeutic importance of this has yet to be
established.
(Daugirdas)
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Am Soc Nephrol
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