Gogusev J, Duchambon P, Giovannini M, Sarfati E, Drueke TB
Expression in pathalogic parathyroid tissue of calcium receptor and
vitamin D receptor gene message
Am Soc Nephrol
J Am Soc Nephrol (abstract)
(Nov) 6:961 1995
The authors examined the expression of CaR and VDR mRNA in 5 primary
hyperparathyroid, 4
uremic hyperparathyroid, and 3 normal parathyroid glands. There was a
striking decrease in the
mRNA levels in both primary and secondary hyperparathyroid glands. The
decrease was more
marked in area of nodular as opposed to diffuse hyperplasia.
Comment: Very interesting but need to see raw data and greater
number of glands
studied (jad).
Comment2::
In this study the authors find similar reductions of receptors in
both primary and secondary (renal) hyperparathyroidism. This supports
previous data and further suggests why such glands are difficult to
suppress with out current approaches to treatment.
(Sherrard)
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Am Soc Nephrol
CRF by problem area :
Bone disease/aluminum